N-Methylpyrrolidone Description:

N-Methylpyrrolidone is an organic substance with the chemical formula C5H9NO, a colorless to light yellow transparent, miscible with any proportion of water, soluble in various organic solvents, such as ether, halogenated hydrocarbons, aromatic hydrocarbons, etc., and almost completely mixed with all solvents.

1-Methyl-2-Pyrrolidone (NMP) is a versatile, water-soluble, polar non-protic solvent. NMP is used as a drug solubilizer and permeation enhancer in humans and animals, but its bioactive properties remain elusive. Here, we report that NMP is a biologically active anti-inflammatory compound that is well tolerated in vivo and shows disease-reducing efficacy in a murine model of atherosclerosis. Mechanistically, NMP increased the expression of the transcription factor Kruppel-like factor 2 (KLF2).

NMP Instruction:

N-Methylpyrrolidone (1-methyl-2-pyrrolidone) is a five-membered cyclic amide. NMP is a widely used industrial organic polar solvent used in the manufacture of adhesives, paints, fuels and pharmaceuticals.

NMP or Pharmasolve are very powerful solubilizers with important applications in different industrial fields. This review describes the physicochemical properties, especially the application in pharmaceutical sciences, pharmacokinetics and toxicity of NMP. The characteristics of NMP, such as physicochemical properties, solubilizing efficacy, toxicity and adverse effects, are compared with other common solvents used in the pharmaceutical industry. This review shows that NMP is an acceptable solvent for pharmaceuticals with efficacy.

NMP Uses:

Excellent advanced solvent, widely used in petrochemicals, pesticides, medical and pharmaceuticals, electronic materials and other fields. NMP can be used in syngas desulfurization, lubricating oil refining, lubricating oil antifreeze, olefin extractant, agricultural herbicide, insulating material, integrated circuit making, PVC exhaust gas recovery, cleaning agent, dye auxiliary, dispersant, etc.