How to Prepare GHB from 1,4-butanediol?

GHB can be prepared from 1,4-butanediol through the following steps:

Step 1: Preparation of γ-butyrolactone
1,4-butanediol and phenylacetic acid are heated and reacted with a certain catalyst to generate γ-butyrolactone. This step is a key step in preparing GHB.

Step 2: Hydrolysis Reaction
Dissolve the γ-butyrolactone obtained in step 1 in water, add sodium hydroxide (NaOH) solution, and fully stir. Through the hydrolysis reaction, γ-butyrolactone is converted to GHB.

How to Prepare GHB from 1,4-butanediol

Step 3: Extraction and Purification
The mixed solution obtained from the hydrolysis reaction is subjected to appropriate extraction and purification steps, for example, extraction with an organic solvent, followed by distillation, etc., to obtain GHB with high purity.

It is important to note that GHB is a regulated psychotropic substance that is listed as illegal or restricted for use in most countries. Before proceeding with any laboratory operation or production, please ensure that relevant laws and regulations are complied with and the corresponding licenses obtained.